The Central Line had severe delays on Friday as emergency services responded to a casualty on the track.
The line reopened after an earlier suspension but is now running with delays while Bethnal Green Tube station is now back open.
Tickets are being accepted on London Buses, Elizabeth Line and London Overground.
RMT action could also see Oxford Circus close at short notice between 10pm on Friday and 6am on Sunday.
A good service was being reported on the rest of TfL network apart from the Northern line where there are minor delays due to a shortage of trains.
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Minor delays on Metropolitan line
Transport for London has warned of minor delays between Moor Park and Amersham / Watford due to train cancellations.
The next departure from Amersham will be at 1.52pm.
Bethnal Green station now open
Bethnal Green station has reopened after an earlier incident.
The Central line Tube station had been closed on Friday morning.
The line is currently experiencing delays.
Central line no longer suspended
The Central line is now severely delayed but is no longer part suspended.
TfL said: “Severe delays due to an earlier customer incident. Tickets are being accepted on London Buses, Elizabeth Line and London Overground.”
Old Street Tube station now also closed
Old Street station is closed due to faulty escalators, TfL has said.
Four day Croydon Tramlink strike to go ahead after 'bad faith' talks
A strike is set to begin this weekend on the Croydon Tramlink after a union accused Transport for London (TfL) of “bad faith” in negotiations.
Unite is holding the walkout from 8pm on Sunday to 6am on Thursday with up to 60 engineers on the south London network set to down tools over pay disparities.
Unite called the strike on Thursday stating that they wanted the pay of tram drivers to come into line with London Underground staff. They said that Tube workers can earn up to £10,000 more for equivalent roles despite both needing the same qualifications.
TfL has denied there was any “bad faith” element of the talks.
Large amount of closures this weekend
The following lines have a restricted service or planned closure this bank holiday weekend due to scheduled works or engineering.
Reduced service
Elizabeth line: Sunday 5 May, the first train from Paddington to Reading will depart at 0700 instead of 0646.
Part closure
District line: Saturday 4, Sunday 5 and Bank Holiday Monday 6 May, no service between Hammersmith / Wimbledon / Kensington (Olympia) and Edgware Road / Embankment.
Circle line: Saturday 4, Sunday 5 and Bank Holiday Monday 6 May, no service between Edgware Road and Tower Hill (via Victoria).
DLR: Saturday 4, Sunday 5 and Bank Holiday Monday 6 May, no service between Westferry / Poplar and Lewisham. Replacement buses operate: Service DL3 between Westferry and Island Gardens and Service DL4 between Canada Water (for Jubilee line) and Lewisham.
Overground: Sunday 5 May, from 2215, no service between Highbury & Islington and Dalston Junction. Replacement buses operate between Camden Road and Stratford via Highbury & Islington, Canonbury and Dalston Junction.
Planned closure
Waterloo and City line: Line does not run at weekends.
Mornington Crescent station closed
Mornington Crescent Tube station is closed due to faulty lifts. It means there are now three closed Tube stations - or four if you include the long term closure of Kentish Town.
TfL has said tickets are being accepted on London buses.
Minor delays on Northern line
There are also minor delays on the Northern line on Friday morning.
A shortage of trains has led Transport for London to flag the alert.
Central line part suspended
There is no service between Leytonstone and Liverpool Street on the Central line on Friday morning as emergency services deal with a casualty on the track.
All trains are otherwise only running westbound and there are severe delays on the rest of the line.
Tickets are being accepted on London Buses, the Elizabeth Line and London Overground.
Two stations closed
Bethnal Green and Oxford Circus stations are both shut on Friday morning.
Bethnal Green is closed while emergency services deal with a casualty on track.
Oxford Circus, meanwhile, is shut due to RMT strike action.